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Masti Express Hai Full Movie Hd 720p IMDb Rating: 5.2/10 Genre: Adventure, Comedy, Drama Director: Vikram Pradhan .The peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) controls sterol balance and metabolism in rats.
The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors of the steroid hormone superfamily that regulate the expression of genes involved in lipid homeostasis. We have studied the role of PPARbeta/delta, a recently discovered member of the PPAR family, in lipid metabolism using adenovirus gene transfer. In PPARbeta/delta-expressing HEK293 cells, the cellular concentration of fatty acids was increased by 1.7-2.5-fold and hepatic sterol synthesis by 1.4-1.6-fold compared with vector-transfected controls. The activity of an acyl-CoA synthetase was increased by 2.0-2.5-fold in PPARbeta/delta-expressing cells, and the activity of acyl-CoA thioesterase was 2.0-2.5-fold higher than in vector-transfected controls. Experiments using the antagonist CGP-30,062 demonstrated that PPARbeta/delta controls the expression of acyl-CoA synthetase and acyl-CoA thioesterase in vivo. Most of the PPARbeta/delta-dependent effects could be blocked by cyclopamine, a selective inhibitor of the hedgehog pathway. We conclude that PPARbeta/delta controls sterol synthesis and regulates the expression of acyl-CoA synthetases in vivo. The physiological relevance of the PPARbeta/delta-dependent regulation of fatty acid synthesis and acyl-CoA synthetase is discussed.Q:
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